Ankyrin 3, also known as Ankyrin G, is larger than the related Ankyrin 1 and Ankyrin 2. Ankyrin 3 is expressed in the axon initial segment and the nodes of Ranvier in the nervous system. Antibodies against Ankyrin 3 thus can be useful in identifying the regions of axon initial segments and nodes of Ranvier. This antibody was made against the C-terminal 398 amino acid of human isotype 1, and works well on human and rat ankyrin 3 on western blots and section material. This segment is expressed by all ankyrin 3 three isotypes and contains the DEATH domain sequence.
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