Human TH (EC 188.8.131.52) is a 58,523 dalton protein (528 amino acids) responsible for the enzymatic conversion of l-tyrosine to l-DOPA (dihydroxyphenylalanine). This enzyme is expressed in all catecholaminergic neurons of the CNS and PNS. In the CNS, TH-positive neurons can be found within the substantia nigra, ventral tegmental area, locus ceruleus, and hypothalamus. In the PNS, TH-positive neurons can be found within the sympathetic chain, pre-vertebral ganglia and the adrenal medulla.
- Product ReviewsI recommend this product Product Name: Tyrosine Hydroxylase – (Cat# CH23006) Organization: Karolinska InstitutetLaura Pozzi - Sep 29, 2013 - Rating: 5.0
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- Yu-Wei Chen, Manasmita Das, Esteban A. Oyarzabal, Qing Cheng, Nicholas W. Plummer, Kathleen G. Smith, Grace K. Jones, Daniel Malawsky, Jerrel L. Yakel, Yen-Yu Ian Shih & Patricia Jensen (2018). Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses. Molecular Psychiatry. DOI https://doi.org/10.1038/s41380-018-0245-8
- Hans-Ulrich Fried, U. Benjamin Kaupp and Frank Müller. (2010). Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice. Cell Tissue Res., 339(3): 463–479. doi: 10.1007/s00441-009-0904-9
- Sujoy K. Dhara, Brian A. Gerwe, Anirban Majumder, Mahesh C. Dodla, Nolan L. Boyd, David W. Machacek, Kowser Hasneen, Steven L. Stice. (2009). Genetic Manipulation of Neural Progenitors Derived from Human Embryonic Stem Cells. Tissue Engineering Part A. doi: 10.1089/ten.tea.2009.0155
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