Product Details
Catalog Number: CH23031
Applications: ICC, WB, IHC
Type: Chicken IgY
Immunogen: Peptide common to human (Q99259, NCBI), mouse (P48318, NCBI) and rat (NP_058703, NCBI) GAD-67
Storage: Store at 4°C in the dark
Shipping: Ambient
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 2571
UniProt: Q99259
Downloads: Datasheet (pdf)
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Glutamic acid decarboxylase (GAD) catalyzes the conversion of glutamic acid to gamma-aminobutyric acid (GABA); which is a major inhibitory neurotransmitter in the higher brain regions and a putative paracrine hormone in pancreatic islets. There are two forms of GAD; GAD65 and GAD67 (65 kDa and 67kDa respectively, with 64% aa identity between forms). GAD67 is a rate limiting enzyme and is responsible for >90% of GABA production in the central nervous system. GAD67 is cytoplasmic and encoded on chromosome 2. GAD67 expression is plastic and can change in response to experimental manipulation or disease progression. GAD67 levels are altered in multiple neuropsychiatric disorders including schizophrenia. 

Images
A tissue section through an adult mouse brain showing GAD-67 (red staining) (cat # CH23031) in basket cells of the hippocampal formation. Photo courtesy of Dr. Felix Eckenstein, University of Vermont

A tissue section through an adult mouse brain showing GAD-67 (red staining) (cat # CH23031) in basket cells of the hippocampal formation. Photo courtesy of Dr. Felix Eckenstein, University of Vermont

A tissue section through an adult mouse brain showing GAD-67 (red staining) (cat # CH23031) in basket cells of the hippocampal formation. Photo courtesy of Dr. Felix Eckenstein, University of Vermont

A tissue section through an adult mouse brain showing GAD-67 (red staining) (cat # CH23031) in basket cells of the hippocampal formation. Photo courtesy of Dr. Felix Eckenstein, University of Vermont