Human CD39 is found on most mature B cells, activated NK cells and activated T cells. CD39 is also weakly expressed on granulocytes. CD39 has homology to the Nmyc family of proteins and was recently cloned. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis
CD39 could ould also play a in type 2 Diabetes
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- Christiane E. Sørensen, Jan Amstrup, Hans N. Rasmussen, Ieva Ankorina-Stark and Ivana Novak. (2003). Rat pancreas secretes particulate ecto-nucleotidase CD39. J Physiol, 551.3, pp. 881-892. doi: 10.1113/jphysiol.2003.049411
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