Product Details
Catalog Number: GP10103
Applications: IHC
Type: Guinea Pig IgG
Dilutions: IHC 1:1000
Immunogen: DAGSSHTNLYIY
Storage: Store frozen. Aliquot as undiluted serum and immediately place at -20ºC.
Format A: Whole serum
Format B: liquid
Species Reactivity: Rat
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
150 ul$395.00Add to Cart
50 ul$175.00Add to Cart

Human CD39 is found on most mature B cells, activated NK cells and activated T cells. CD39 is also weakly expressed on granulocytes. CD39 has homology to the Nmyc family of proteins and was recently cloned. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis

CD39 could ould also play a in type 2 Diabetes

Images
CD39 distribution in rat pancreatic ducts. J Physiol (2003), 551.3, pp. 881-892 © Copyright 2003 The Physiological Society. DOI: 10.1113/jphysiol.2003.049411

CD39 distribution in rat pancreatic ducts. J Physiol (2003), 551.3, pp. 881-892 © Copyright 2003 The Physiological Society. DOI: 10.1113/jphysiol.2003.049411

CD39 distribution in rat pancreatic ducts. J Physiol (2003), 551.3, pp. 881-892 © Copyright 2003 The Physiological Society. DOI: 10.1113/jphysiol.2003.049411

CD39 distribution in rat pancreatic ducts. J Physiol (2003), 551.3, pp. 881-892 © Copyright 2003 The Physiological Society. DOI: 10.1113/jphysiol.2003.049411

Detection of immunoreactive CD39 and CD73 in the effluent of ischemia reperfusion. Takahashi-Sato et al. BMC Cardiovascular Disorders 2013 13:53 doi:10.1186/1471-2261-13-5

Detection of immunoreactive CD39 and CD73 in the effluent of ischemia reperfusion. Takahashi-Sato et al. BMC Cardiovascular Disorders 2013 13:53 doi:10.1186/1471-2261-13-5