Product Details
Catalog Number: GP14104
Applications: IHC
Type: Guinea Pig IgG
Immunogen: GASSEDTLLKDAAKVCR
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 7345
UniProt: P09936
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
150 ul$399.00Add to Cart
50 ul$179.00Add to Cart

PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.

 It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for  cells of the diffuse neuroendocrine system and their tumors

Supporting Products
NameCatalog #Size
PGP9.5 175-191P1013520 ug Blocking Peptide
Images

PGP9.5 175-191staining of the synovium from ASIC3 +/+ mice with joint inflammation.  Bar = 25 μm.

PGP9.5 175-191staining of the synovium from ASIC3 +/+ mice with joint inflammation. Bar = 25 μm. doi: 10.1016/j.pain.2008.01.020.

PGP9.5 175-191staining of the synovium from ASIC3 +/+ mice with joint inflammation.  Bar = 25 μm.

PGP9.5 175-191staining of the synovium from ASIC3 +/+ mice with joint inflammation. Bar = 25 μm. doi: 10.1016/j.pain.2008.01.020.