Microglia, one of the glial cell types in the CNS, is an important integral component of neuroglia cell network. They have been observed in the brain parenchyma from the early stage of development to the mature state. Microglia act as brain macrophages when programmed cell death occurs during brain development or when the CNS is injured or pathologically damaged.
Microglia can be considered as the main cell in brain immune surveillance, can present antigens in the molecular context of MHC class II expression to CD-4 positive T cells, are capable of Fc mediated phagocytosis, and share many common antigens with hemopoietic and tissue macrophages. Furthermore, there is accumulating evidence that microglia are involved in a variety of physiological and pathological processes in the brain by interacting with neurons and other glial cells and through production of biologically active substances such as growth factors, cytokines, and other factors.
Human brain microglia cells are isolated from healthy human brain tissue. After purification, HBMCs are cryopreserved and delivered frozen. HBMCs are ready to plate in a culture vessel for experiment.