Synaptophysin is a 38 kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroblastomas.
It is also suspected to play a role in Respiratory Disorders (i.e. sleep apnea) and Lewy Body Neurodegenerative Diseases.
Customer Testimonial: "The synaptophysin antibody works very nice. We are currently using it to verify membrane localization of other proteins for IHC, and as a membrane fraction loading control for western. I think we will have a publication sent out soon using it, I'll let you know." Courtesy of Dan Harrigan, Mitchell Lab, UW-Madison.
- Product Reviews
- Product Publications
- Lilith Torres and Richard J Noel. (2014). Astrocytic expression of HIV-1 viral protein R in the hippocampus causes chromatolysis, synaptic loss and memory impairment. Journal of Neuroinflammation, 11:53. doi: 10.1186/1742-2094-11-53
- C.H. Guenther, S. Vinit, J.A. Windelborn, M. Behana and G.S. Mitchell. (2010). Atypical protein kinase C expression in phrenic motor neurons of the rat. Neuroscience, doi: 10.1016/j.neuroscience.2010.05.018
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size α-Internexin/NF 66 MO22154 100 ul 5HT (Serotonin) GT20079 100 ul 5HT (Serotonin) -High Titer RA20080 100 ul 5HT (Serotonin) Transporter RA22153 100 ul 5HT (Serotonin) Transporter RA24330 100 ul ABCA1 MO13101 100 ul APP RA18003 100 ul APP 228 MO20015 100 ul GABA B Receptor1 RA20003 100 ul mGluR2/3 RA13102 100 ul mGluR5 RA16100 50 ug mGluR5b RA13106 100 ul Oxytocin RA24604 100 ul Semaphorin 5A GT41026 100 ug Somatostatin RA21026 50 ug Somatostatin Receptor-1-SSTR1 RA25004 100 ul Somatostatin Receptor-2-SSTR2 RA25005 100 ul Synaptophysin (SYP) RA21027 50 ug