Product Details
Catalog Number: MO20005
Applications: IHC
Type: Mouse IgG
Immunogen: Prokaryotic recombinant fusion protein corresponding to the full external domain of the human CD1a molecule.
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human
Downloads: SDS (pdf)
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$180.00Add to Cart

CD1a is a protein of 43 to 49kD expressed on dendritic cells and cortical thymocytes. CD1a antigen expression has been shown to be useful in differentiating Langerhans cells, powerful antigen presenting cells present in skin and epithelia, from interdigitating cells. Immunohistochemical studies for CD1a antigen have reported a reduction in epidermal Langerhans cells in graft versus host disease and the participation of CD1a antigen-positive dendritic cells in atherosclerotic lesion formation and asthmatic inflammation.

Clone MTB1 detects cortical thymocytes, Langerhans cells in epidermis, interdigitating cells of dermis and interdigitating cells of stratified squamous epithelium of tonsil. Clone MTB1 may also detect small focal groups of lymphocytes outside the germinal centers of tonsil indicating a cross-reaction with CD1b antigen 

Images
CD1a (clone MT1B) staining of paraffin embedded human skin tissue (normal). Note intense membrane staining of Langerhans cells.

CD1a (clone MT1B) staining of paraffin embedded human skin tissue (normal). Note intense membrane staining of Langerhans cells.

CD1a (clone MT1B) staining of paraffin embedded human skin tissue (normal). Note intense membrane staining of Langerhans cells.

CD1a (clone MT1B) staining of paraffin embedded human skin tissue (normal). Note intense membrane staining of Langerhans cells.