Proliferating cell nuclear antigen (PCNA) is a 36kD protein which is highly conserved between species. PCNA functions as a co-factor for DNA polymerase delta in S phase and also during DNA synthesis associated with DNA damage repair mechanisms. The PCNA molecule has a half-life in excess of 20 hours, and therefore, may be detected in non-cycling cells eg those in G0 phase.
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- Wei Han, Gui-Nan Liu. (2009). EGR-1 decoy ODNs inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia of balloon-injured arteries in rat. Life Sciences, doi: 10.1016/j.lfs.2009.12.005
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