Glial Fibrillary Acidic Protein (GFAP) is strongly and specifically expressed in astrocytes, Bergmann glia and certain other glia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves (1-3). GFAP expression is also seen in developing neural stem cells and GFAP levels may greatly increase in regions of CNS injury or disease (4), and point mutations in the GFAP gene are causative of Alexander's disease (5). Antibodies to GFAP such as MCA-2A5 are useful for visualizing glia and monitoring developmental, disease and damage related CNS alterations.
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