Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. In the electron microscope, neurofilaments appear as 10nm diameter fibers of indeterminate length which generally have fine wispy protrusions from their sides. They are found particularly abundantly in axons of large projection neurons. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable.
This antibody recognizes phosphorylated NF-H KSP (lysine-serine-proline) type sequences. In some species, there is some cross-reactivity with the related phosphorylated KSP sequences found in the related neurofilament subunit NF-M. The antibody recognizes NF-H strongly in all mammals tested to date and also in chicken. It recognizes neurofilaments in frozen sections in tissue culture and in formalin fixed sections
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- Serena Quarta, Bastian E. Baeumer, Nadja Scherbakov, Manfred Andratsch, Stefan Rose-John, Georg Dechant, Christine E. Bandtlow, and Michaela Kress. (2014). Peripheral Nerve Regeneration and NGF-Dependent Neurite Outgrowth of Adult Sensory Neurons Converge on STAT3 Phosphorylation Downstream of Neuropoietic Cytokine Receptor gp130. The Journal of Neuroscience, 34(39): 13222-13233; doi: 10.1523/JNEUROSCI.1209-13.2014
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