Tar DNA Binding Protein, TDP43 or TARDBP was originally identified as a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. It was also reported to regulate alternate splicing of the CFTR gene and the apoA-II gene.
Later it was discovered that hyper-phosphorylated, ubiquitinated and cleaved form of TARDBP, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in Amyotrophic lateral sclerosis (ALS). Elevated levels of the TDP-43 protein have also been identified in individuals diagnosed with chronic traumatic encephalopathy, a condition that often mimics ALS and that has been associated with athletes who have experienced multiple concussions and other types of head injury.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size 39C7-a Panspecific Nuclear Pore Complex Marker MO22107 500 ul ATPase Na+/K+ transporting alpha 1 MO25023 50 ul Fibrillarin MO22169 100 µl Fibrillarin/Nop1p- Nucleolar Marker MO22108 500 ul FluoGreen Tracer SF41000 100 ul GFP GT22101 100 ul Green Fluorescent Protein (GFP) CH23105 400 ul High-mobility group protein B1/HMGP1 MO22134 100 ul Lamin A/C MO22124 100 ul mCherry - Mouse MO22140 100 ul mCherry-Chicken CH22115 100 ul mCherry-Rabbit RA22117 100 ul TAF15 MO22114 100 ul