Fox3 is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46kDa proteins each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices. An alternate name for Fox 3 is hexaribonucleotide binding protein 3, and these proteins are believed to have a role in the regulation of mRNA splicing.
Much interest has focused on Fox3 as this protein corresponds to NeuN, a neuronal nuclear antigen. NeuN antibody has become very widely used as a robust marker of neurons and neuronal stem cells. Fox3 is therefore a protein which has a funciton in RNA splicing and is expressed heavily and specifically in neuronal nuclei.
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- Weike Deng, Fei Luo, Bao-ming Li, Lin Mei (2019). NRG1–ErbB4 signaling promotes functional recovery in a murine model of traumatic brain injury via regulation of GABA release. Experimental Brain Research. https://doi.org/10.1007/s00221-019-05680-2
- Sreyashi Samaddar, Kizzy Vazquez, Dipen Ponika, Pedro Toruno, Karim Sahbani, Sultana Begum, Ahmed Abouelela, Wagdy Mekhael, Zaghloul Ahmed. (2016). Trans-spinal direct current stimulation modulates migration and proliferation of adult newly-born spinal cells in mice. Journal of Applied Physiology, doi: 10.1152/japplphysiol.00834.2016
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