Product Details
Catalog Number: MO22130
Applications: WB, IF
Type: Mouse IgG
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Bovine
Entrez: 3169
UniProt: P55317
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$325.00Add to Cart

Fox1 is one of a family of 3 mammalian Fox1 homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46kDa proteins each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices.  An alternate name for Fox 1 is ataxin-2 binding protein 1 (A2BP1).

Like Fox3 (Mouse Monoclonal FOX3 Antibody, MO22122), Fox1 is expressed in neuronal nuclei, but with a different pattern of expression than Fox3. For example, in the cerebellum, Fox3 does not stain Purkinje neurons and Golgi neurons, but these two neuron types are stained by Fox1 antibody

Images

Rat brain neural cultures stained with FOX1 (green), and our rabbit polyclonal antibody to NF-M (RA22105, green) and DNA (blue). This antibody reveals nuclear and distal cytoplasmic staining for Fox1, and the complete absence of staining of non-neuronal cells.Protocol on Data-sheet.

Rat brain neural cultures stained with FOX1 (green), and our rabbit polyclonal antibody to NF-M (RA22105, green) and DNA (blue). This antibody reveals nuclear and distal cytoplasmic staining for Fox1, and the complete absence of staining of non-neuronal cells.Protocol on Data-sheet.

Blots of mouse brain homogenates stained with Fox1. Antibody binds closely spaced 48kDa and 46kDa bands. Protocol on Data-sheet.

Blots of mouse brain homogenates stained with Fox1. Antibody binds closely spaced 48kDa and 46kDa bands. Protocol on Data-sheet.