Amyloid beta-protein (Abeta) is associated with neuronal injury and death in Alzheimer's disease. These proteins are the main components of amyloid plaques. Abeta 42 plays a bigger role in neurogeneration and is more strongly associated with Alzheimer's disease than Abeta 40.
Image: Immunohistochemical analysis of paraffin-embedded Alzheimer’s hippocampus using Thioflavin S (left panel) and MO22141 using the HRP-DAB staining technique. Left image shows a section stained with Thioflavin S, a fluorescent reagent which binds to both senile plaques (SP) and neurofibrillary tangles (NFT), the two hallmark lesions of Alzheimer’s disease. Lipofuscin granules (LP) are seen in normal aging brain, but are autofluorescent and so can also be seen in this image. MO22141 show strong staining only of the senile plaques. The right image show MO22141 staining of an adjacent section, showing strong staining of the senile plaques, with more minor staining of blood vessels.
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