Product Details
Catalog Number: MO22145
Applications: ICC, WB, IHC, IF
Type: Mouse IgG
Immunogen: Recombinant full length version of the shortest human Tau isoform purified from E. col
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Species Reactivity: Human, Mouse, Rat, Primate, Chicken
Entrez: 4137
UniProt: P10636
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$325.00Add to Cart

Tau is a relatively low molecular weight member of the microtubule associated protein or MAP. The recombinant protein used to make this antibody is the shortest version of the 8 human tau proteins, so the antibody is expected to bind to all 8 isoforms.

Tau is heavily concentrated in axons of neurons, but may also be found in dendrites and in some non neuronal cells. Much interest has focused on tau as it is a major component of the neurofibrillary tangles of Alzheimer’s disease . 

Images

E18 hippocampal neurons were grown for seven days following the protocol. We fixed and immunostained with MO22145 (green) using our standard immunostaining protocol (on datasheet), chicken antibody to α-internexin (CH22101 red) and for DNA (blue). MO22145 stains the neuronal perikarya and process strongly, and does not stain non neuronal cells in these cultures. The α-internexin antibody stains intermediate or 10nm filament bundles in the cytoplasm of these cells.

E18 hippocampal neurons were grown for seven days following the protocol. We fixed and immunostained with MO22145 (green) using our standard immunostaining protocol (on datasheet), chicken antibody to α-internexin (CH22101 red) and for DNA (blue). MO22145 stains the neuronal perikarya and process strongly, and does not stain non neuronal cells in these cultures. The α-internexin antibody stains intermediate or 10nm filament bundles in the cytoplasm of these cells.