Ubiquitin is a highly conserved globular 76 amino acid protein of about 8.5 kDa molecular weight. It has an important role in the targeting of proteins for proteolytic degradation. Proteins to be degraded are covalently coupled to the C-terminus of ubiquitin by means of ubiquitin ligases. The ubiquitin itself is frequently also ubiquitinated, producing a polyubiquitin chain. The polyubquitinated complex is then recognized by a complex of degradative enzymes which together form the proteosome. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions seen in serious human disease states which appear to be resistant to normal degradation, so that ubiquitin antibodies are very useful for studies of these inclusions. For example the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer’s disease, the Lewy bodies seen in Parkinson’s disease, and Pick bodies found in Pick’s disease are all heavily ubiquitinated and can all be readily visualized with ubiquitin antibodies of appropriate specificity.
MO22152 was raised against purified ubiquitin conjugated with glutaraldehyde to keyhole limpet hemocyanin. This antibody can used to study ubiquitinated inclusions seen in Alzheimer’s and other kinds of disease; such as such as the Lewy bodies of Parkinson’s disease and the Pick bodies in Pick’s disease in formalin fixed tissues. It can be used on mildly fixed histological sections of human brain, and paraffin embedded material.
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Name Catalog # Size alpha Synuclein CH22139 100 ul alpha Synuclein MO22111 100 ul BACE1 RA21010 50 ug Beta-Synuclein RA22141 100 ul GABA A receptor alpha 4 GT41008 100 ug GABA A Receptor beta 3 GT41011 100 ug GABA Receptor Associated Protein RA19014 100 ug GluR2/AMPA2 RA30012 50 ug GluR4/AMPA4 GT41012 100 ug Nicotinic acetylcholine receptor alpha7 GT41009 100 ug NMDA NR1 Pan MO25041 15 ug NMDA Receptor 1, N1 RA25036 25 ug NMDA Receptor 2A RA25037 100 ul NMDA Receptor 2B RA25063 100 ul P2X1 RA10107 150 ul P2X1 RA10107 50 ul P2X2 GP14106 150 ul P2X2 GP14106 50 ul P2X2 RA10108 150 ul P2X2 RA10108 50 ul P2X3 GP10108 100 ul P2X3-Pure RA14139 100 ul p504s/AMACR (α-Methylacyl Coenzyme A Racemase) MO47014 100 ul phospho-NMDA Receptor 1 (Ser890) RA18011 100 ul Phospho-NMDA Receptor 1 (Ser896) RA18012 100 ul PSAP (Prostatic Specific Acid Phosphatase)/PAP MO47053 100 ul S-100 MO47059 100 ul Ubiquitin RA22154 100 ul