α-internexin is a Class IV intermediate filament protein originally discovered by two different groups of researchers as it copurifies with NF-L, NF-M and NF-H, the then better known major neurofilament “triplet” subunits. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Some neurons express α-internexin in the absence of NF-L, NF-M and NF-H, though most mature neurons express all four proteins. This α-internexin antibody has been shown, in peer reviewed publications, to reveal the upregulation of α-internexin in facial neurons following experimental axotomy followed by down regulation on axonal regeneration. It is also the standard reagent used to identify and classify patients with neurofilament inclusion body disease, a specific form of frontotemporal lobar dementia. Finally, it has been used to confirm the presence of circulating antibodies to α-internexin in the blood of certain patients with endocrine autoimmunity.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size 5HT (Serotonin) GT20079 100 ul 5HT (Serotonin) -High Titer RA20080 100 ul 5HT (Serotonin) Transporter RA22153 100 ul 5HT (Serotonin) Transporter RA24330 100 ul ABCA1 MO13101 100 ul APP RA18003 100 ul APP 228 MO20015 100 ul GABA B Receptor1 RA20003 100 ul mGluR2/3 RA13102 100 ul mGluR5 RA16100 50 ug mGluR5b RA13106 100 ul Oxytocin RA24604 100 ul Semaphorin 5A GT41026 100 ug Somatostatin RA21026 50 ug Somatostatin Receptor-1-SSTR1 RA25004 100 ul Somatostatin Receptor-2-SSTR2 RA25005 100 ul Synaptophysin MO20000 100 ul Synaptophysin (SYP) RA21027 50 ug