Product Details
Catalog Number: MO25039
Applications: IHC
Type: Rabbit IgG
Immunogen: Full-length proHD5 protein. [Swiss-Prot# Q01523] The propeptide is the full-length protein. In the mature form, it is cleaved at residue 63 (alanine).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Ascites Fluid
Format B: liquid
Species Reactivity: Human
Entrez: 1670
UniProt: Q01523
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$285.00Add to Cart

Human neutrophil alpha-defensins (also designated HNPs) are small, cationic, cysteine-rich antimicrobial proteins that play important roles in innate immunity against infectious microbes such as bacteria, fungi and enveloped viruses. Alpha-defensins are synthesized as inactive precursors and are activated by proteolytic cleavage by MMP-7. Paneth cells in small intestinal crypts secrete the alpha-defensins, which are also termed cryptidins in mice. Alpha-defensins 5 and 6 probably contribute to innate defense of the GI mucosal surface by protecting against microbial invasion in states of intestinal inflammation.

Images
Defensin 5 staining of Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining.

Defensin 5 staining of Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining.

Defensin 5 staining of Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining.

Defensin 5 staining of Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining.