There are several challenges associated with In vitro neurological research. Specifically, there is a challenge in establishing batch-to-batch consistency, as well as high expansion capability. Induced pluripotent stem cell (iPSC)-derived neuronal progenitor cells have high yield capability and can differentiate into various neurological cells types, making them an ideal model for basic science, regenerative medicine and drug discovery. Our patient-derived human neuronal progenitor cells were made from PBMCs, collected from substance abusing patients. The cells may be used for experimental applications including drug development, neurotoxicity, neurogenesis, and electrophysiology.