G protein-coupled receptors (GPCRs) are the largest family ofmembrane receptors that activate intracellular signalingcascades and undergo endocytosis, recycling, or degradationupon stimulation. The (mu) m-, delta (d) and kappa (k) opioid receptors areGPCRs of the nervous system, which control pain, stress, andaddictive behaviors. The delta opioid receptor (DOR-1) is the stereoselective receptor for enkephalins and inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance
Image: Western blot analysis with DOR at a dilution of 1:500. Lane 1: 10 ug of human brain lysate and Lane 2: 10 ug rat brain lysate
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