Product Details
Catalog Number: P24287
Type: Peptide
Storage: Store at 4°C short term. Store at -20°C for maximum stability. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Frozen
Format B: liquid
Downloads: Datasheet (pdf)
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50 ug Blocking Peptide$95.00Add to Cart

nNOS-C-terminus (Neuronal Nitric Oxide Synthase) Blocking Peptide; specific to RA24287

Human nitric oxide synthases are a family of enzymes responsible for the synthesis of nitric oxide from L-arginine and molecular oxygen. There are at least three nitric oxide synthases; NOS I, also known as neuronal NOS or nNOS, NOS II, which is referred to as inducible NOS or iNOS and NOS III, also known as endothelial NOS or eNOS. nNOS plays a role in the upregulation of microglial phospho-p38 MAPK. Such p38 MAPK activation in microglia is consistent with a potential role in the development of morphine antinociceptive tolerance. 

nNOS is expressed in the hypothalamus, striatum, cortex, spinal cord and PNS. In ischemic stroke, nNOS activation is linked to Neural Damage.

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