This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined. SNX26 may be involved in several stages of intracellular trafficking. It could play an important role in the regulation of glucose transport by insulin. It may act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport.
Image: SNX26 staining of human brain (formalin-fixed paraffin-embedded) at 2.5 ug/ml Steamed antigen retrieval with citrate buffer pH 6 followed by biotinylated horse anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.
Note: In paraffin embedded Human Brain shows cytoplasm staining of Purkinje cells in Cerebellum.
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