FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
1. A polyvinyl alcohol core coil containing basic fibroblast growth factor evaluated in rabbits with aneurysms induced by elastase. Neurosurgery 2007 Jul;61(1):160-6
- Product Reviews
- Product Publications
- G. Criscenti, C. De Maria, A. Longoni, C. van Blitterswijk, H. Fernandes, G. Vozzi, L. Moroni. (2018). Soft-Molecular Imprinted Electrospun Scaffolds to Mimic Specific Biological Tissues.IOP Science. Doi: 10.1088/1758-5090/aad48a
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size FGF (154), basic PR29000 1 mg FGF (154), basic PR29000 10 ug FGF (154), basic PR29000 50 ug FGF-1, acidic PR27011 10 ug FGF-1, acidic PR27011 50 ug FGF-1, acidic, Sf9 PR27012 10 ug FGF-1, acidic, Sf9 PR27012 2 ug FGF-19 PR27019 25 ug FGF-19 PR27019 5 ug FGF-2 (Bovine) basic PR27015 10 ug FGF-2 (Bovine) basic PR27015 50 ug FGF-2, basic PR27013 10 ug FGF-2, basic PR27013 50 ug FGF-2, basic, Sf9 PR27014 10 ug FGF-2, basic, Sf9 PR27014 2 ug FGF-22 PR27021 10 ug FGF-22 PR27021 2 ug FGF-9 PR27017 2 ug FGF-9 PR27017 20 ug FGF-9, mouse PR27018 10 ug FGF-9, mouse PR27018 2 ug ISOKine-bFGF PR80001 10 ug ISOKine-bFGF PR80001 100 ug ISOKine-bFGF PR80001 50 ug KGF Human PR27047 10 ug KGF Human PR27047 2 ug KGF-2 PR27048 25 ug KGF-2 PR27048 5 ug