Product Details
Catalog Number: PR27022
Type: Protein
Storage: Store at room temperature for up to 3 weeks. Store desiccated at -20°C. Avoid freeze-thaw cycles.
Shipping: Ambient
Format B: lyophilized
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
10 ug$205.00Add to Cart
2 ug$108.00Add to Cart

GDNF promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. GDNF enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.  

References:

1. Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways. Brain Res Bull 2006 Dec 11;71(1-3):116-26
2. Glial-derived neurotrophic factor modulates enteric neuronal survival and proliferation through neuropeptide Y. Gastroenterology 2006 Oct;131(4):1164-78
3. MRI volumetric and intensity analysis of the cerebellum in Parkinson's disease patients infused with glial-derived neurotrophic factor (GDNF).Exp Neurol 2006 Apr;198(2):450-6
4. Ischemia-related changes of glial-derived neurotrophic factor and phosphatidylinositol 3-kinase in the hippocampus: their possible correlation in astrocytes. Brain Res 2006 Feb 9;1072(1):215-23
5. Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors Increased yield of dopamine cells is dependent on embryonic donor age. Brain Res Bull 2005 Dec 15;68(1-2):31-41
6. Effects of fibroblast growth factor and glial-derived neurotrophic factor on akinesia, F-DOPA uptake and dopamine cells in parkinsonian primates.Parkinsonism Relat Disord 2002 Jun;8(5):311-23.
  • Product Reviews
    We ordered growth factors for stem cell differentiation. The products came quickly and smoothly.
    Richard Sam - Apr 18, 2019 - Rating: 5.0
    Excellent products! Reagents works well. I’ll keep ordering my reagents here.
    Karla P. Ramos - Aug 11, 2018 - Rating: 5.0
    Great and fast service Got the product in a prompt manner! Product Name: Recombinant Human Glial-Derived Neurotrophic Factor, 10 ug. Recombinant human BDNF, 5 ug Organization: University of Illinois at Urbana-Champaign
    Yongdeok Kim - Sep 13, 2017 - Rating: 5.0
    Neuromics provided very good customer service and support. I ordered their GFP+ Primary Motor Neuron Kit for testing. Unique product that fit our needs perfectly. Highly recommended! Product Name: Mouse Motor Neurons-GFP+ – (Cat# mMN7205-HTS) http://bit.ly/1QvvJFK GDNF (Human, Mouse), recombinant protein – (Cat# PR27022) http://bit.ly/1fF0kKu Organization: Aquinnah – LabCentral
    Tara Vanderweyde - Dec 18, 2015 - Rating: 5.0
    I ordered their product PR27022-10 Recombinant Human Glial-Derived Neurotrophic Factor, 10 ug. The product was delayed and I was promptly informed of the new shipping updates. Overall service was reliable and fast. Product Name: GDNF – (Cat# PR27022) http://bit.ly/1fF0kKu Organization: City College of New York
    Tanya - Jul 29, 2014 - Rating: 4.0
    Fast shipping Product Name: Recombinant Human Glial-Derived Neurotrophic Factor – (Cat# PR27022) http://bit.ly/1fF0kKu Organization: University of Illinois
    Caroline - Feb 07, 2014 - Rating: 4.0

    Leave a review for this product and you could be eligible for a $10 Starbucks gift card. 

  • Product Publications
    Product Publications

    If you've used this product in a publication, let us know. Email rose@neuromics.com, with the publication details and you could be eligible for an Amazon gift card.  

  • Related Products
Images

Immunofluorescence for hN2 Human Neurons Discovery Kit differentiated in the presence of 25 ng/ml GDNF. Cells were also counterstained for nuclei (DAPI) and Tuj 1-Neuron-specific class III beta-tubulin and TH-Tyrosine Hydroxylase.

Immunofluorescence for hN2 Human Neurons Discovery Kit differentiated in the presence of 25 ng/ml GDNF. Cells were also counterstained for nuclei (DAPI) and Tuj 1-Neuron-specific class III beta-tubulin and TH-Tyrosine Hydroxylase.