CD146 (433-647 a.a.) belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130 kDa in its reduced form
1. Role of CD146 in detection of apoptotic circulating endothelial cells in obstructive sleep apnea. Am J Respir Crit Care Med 2007 Jun 15;175(12):1346-1347; author reply 1347
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