KGF Human

KGF is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.

References:

1. KGF promotes integrin alpha-5 expression through CCAAT/enhancer-binding protein-beta. Am J Physiol Cell Physiol 2007 Jun 27.
2. The combination of IGF-I and KGF cDNA improves dermal and epidermal regeneration by increased VEGF expression and neovascularization. Gene Ther 2007 May 31.
3. AKT and MAPK signaling in KGF-treated and UVB-exposed human epidermal cells. J Cell Physiol 2007 Sep;212(3):633-42.
4. Inhibition of proliferation of Pseudomonas aeruginosa by KGF in an experimental burn model using human cultured keratinocytes. Burns 2007 Aug;33(5):613-20.
5. The World Health Organization reference reagent for keratinocyte growth factor, KGF. Growth Factors 2006 Dec;24(4):279-84.
6. Interpenetrating polymer networks containing gelatin modified with PEGylated RGD and soluble KGF: Synthesis, characterization, and application in in vivo critical dermal wound. J Biomed Mater Res A 2007 Mar 2.