Osteostat is the cytokine that binds to TNFRSF18/AITR/GITR and is important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues. Osteostat is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells after stimulation by lipopolysaccharides. Osteostat protein is detectable in human microvascular EC and is highly up-regulated by IFN-alpha and IFN-beta. Osteostat inhibit differentiation of osteoclasts from monocytic precursor cells. Osteostat suppresses the early stage of osteoclastogenesis via inhibition of macrophage colony-stimulating factorinduced receptor activator of NF-kappaB (RANK) expression in the osteoclast precursor cells. Osteostat does not inhibit lipopolysaccharide-induced RANK expression in monocytes and dendritic cells, or activation-induced RANK expression in T cells. Osteostat is a novel regulator of osteoclast generation and substantiate the major role played by the endothelium in bone physiology.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Cardiotrophin 1 PR27092 2 ug Cardiotrophin 1 PR27092 5 ug CXCL7/NAP-2 PR27118 10 ug CXCL7/NAP-2 PR27118 2 ug IL-17 PR27113 25 ug IL-17 PR27113 5 ug IL-3 Human PR27075 10 ug IL-3 Human PR27075 2 ug IL-3 Mouse PR27076 10 ug IL-3 Mouse PR27076 2 ug IL-3 Rat PR27077 10 ug IL-3 Rat PR27077 2 ug IL-6 PR27107 20 ug IL-6 PR27107 5 ug IL-6, His Tagged PR27108 10 ug IL-6, His Tagged PR27108 50 ug Macrophage Inflammatory Protein-3 alpha (CCL20) PR27176 20 ug Oncostatin-M PR27041 10 ug Oncostatin-M PR27041 2 ug TRAIL/APO 2 Ligand PR27058 10 ug TRAIL/APO 2 Ligand PR27058 50 ug Transferrin PR27219 1 gr Transferrin PR27219 100 mg Visfatin (PBEF), His Tagged PR27140 25 ug Visfatin (PBEF), His Tagged PR27140 5 ug