PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB.
1. Expression of survivin, platelet-derived growth factor A (PDGF-A) and PDGF receptor alpha in primary central nervous system lymphoma. J Neurooncol 2006 Sep;79(2):171-9.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size PD-ECGF PR15044 10 ug PDGF - A Human PR27059 20 ug PDGF - A Human PR27059 5 ug PDGF - AB Human PR27062 10 ug PDGF - AB Human PR27062 2 ug PDGF - B Human PR27060 20 ug PDGF - B Human PR27060 5 ug PDGF, CF Human PR15024CF 1 ug PDGF, CF Human PR15024CF 5 ug PDGF-BB PR15027 50 ug PDGF-BB, CF PR15026CF 10 ug PDGF-BB, CF PR15026CF 50 ug PDGF-BB, CF PR15027CF 50 ug