Product Details
Catalog Number: PR27075
Type: Protein
Storage: Store at room temperature for up to 3 weeks. Store desiccated at -20°C. Avoid freeze-thaw cycles.
Shipping: Ambient
Format B: lyophilized
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
10 ug$175.00Add to Cart
2 ug$75.00Add to Cart

IL3 is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. 

Interleukin-3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 133 amino acids and having a molecular mass of 15000 Dalton. 
The IL-3 is purified by proprietary chromatographic techniques.

References:
1. Effect of allergen-specific immunotherapy on recombinant human interleukin 3-mediated amplification of allergen-induced basophil histamine release.  Allergy Asthma Proc 2005 Nov-Dec;26(6):456-62.
2. Secretion of functional human interleukin-3 from Bacillus subtilis.  J Biotechnol 2006 May 17;123(2):211-24.
3. Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression.  Blood 2005 Oct 1;106(7):2527-9.
4. Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys.  Leuk Lymphoma 2004 Aug;45(8):1647-56.
5. [Radioprotection of recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor on peripheral lymphocytes of rhesus monkey irradiated by 3.0 Gy gamma-rays]  Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004 Jan;16(1):22-5.
6. Molecular cloning, expression, purification, and characterization of soluble full-length, human interleukin-3 with a baculovirus-insect cell expression system.  Protein Expr Purif 2003 Sep;31(1):34-41.
Images

IL-3 Human Structure and Sequence

IL-3 Human Structure and Sequence