Leptin is a protein hormone with important effects in regulating body weight, metabolism and reproductive function. The protein is approximately~16 kDa in mass and encoded by the obese (ob)gene. leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cellsin the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells.
Neuromics’ Leptin Quadruple Antagonist Mutant recombinant protein is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transected with the long form of human Leptin receptor. It also inhibits various Leptin effects in several in vitro bioassays.
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Name Catalog # Size Leptin His Tag-Human PR27098 25 ug Leptin His Tag-Human PR27098 5 ug Leptin tA-Human PR27102 10 ug Leptin tA-Human PR27102 50 ug Leptin-Human PR27097 1 mg Leptin-Human PR27097 200 ug Leptin-Mouse PR27099 1 mg Leptin-Mouse PR27099 200 ug Leptin-Pig PR27137 100 ug Leptin-Pig PR27137 20 ug Leptin-Rat PR27100 1 mg Leptin-Rat PR27100 200 ug