Visfatin, also known as pre-B cell colony-enhancing factor (PBEF), is a cytokine that is highly expressed in visceral fat and was originally isolated as a secreted factor that synergizes with IL-7 and stem cell factors to promote the growth of B cell precursors. Visfatin homologs have been identified in carp, invertebrate mollusks, and bacteria, as well as in vertebrates, including humans and the mouse. It has been postulated to play a role in innate immunity.
Visfatin exerts insulin-mimetic effects that are dose-dependent and quantitatively similar to those of insulin in stimulating muscle and adipocyte glucose transport, and in inhibiting hepatocyte glucose production. Intravenous injection of recombinant visfatin in mice decreased plasma glucose in a dose-dependent fashion. In keeping with its insulin-mimetic effects, visfatin was as effective as insulin in reducing hyperglycemia in insulin-deficient diabetic mice. Visfatin was also found to be bound to and activate insulin receptor, causing receptor phosphorylation and the activation of downstream signaling molecules. However, visfatin and insulin did not compete for binding to the insulin receptor, indicating that the two proteins were recognized by different regions of the receptor. Thus, visfatin might play a role in glucose homeostasis and dysregulation in biosynthesis or signal transduction, and might contribute to the pathogenesis of diabetes.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size AITRL Human PR27057 20 ug AITRL Human PR27057 5 ug Cardiotrophin 1 PR27092 2 ug Cardiotrophin 1 PR27092 5 ug CXCL7/NAP-2 PR27118 10 ug CXCL7/NAP-2 PR27118 2 ug GMCSF/IL3 FP Human PR27073 10 ug GMCSF/IL3 FP Human PR27073 2 ug IL-17 PR27113 25 ug IL-17 PR27113 5 ug IL-3 Human PR27075 10 ug IL-3 Human PR27075 2 ug IL-3 Mouse PR27076 10 ug IL-3 Mouse PR27076 2 ug IL-3 Rat PR27077 10 ug IL-3 Rat PR27077 2 ug IL-6 PR27107 20 ug IL-6 PR27107 5 ug IL-6, His Tagged PR27108 10 ug IL-6, His Tagged PR27108 50 ug Macrophage Inflammatory Protein-3 alpha (CCL20) PR27176 20 ug Oncostatin-M PR27041 2 ug Oncostatin-M PR27041 5 ug TRAIL/APO 2 Ligand PR27058 10 ug TRAIL/APO 2 Ligand PR27058 50 ug Transferrin PR27219 1 gr Transferrin PR27219 100 mg