Pre-mRNA-splicing factor SPF27 (BCAS2) is a ubiquitously expressed nuclear protein that was initially identified as being overexpressed in various breast cancer cell lines. BCAS2 is currently as a component of the spliceosome, participating in the exclusion of introns from mRNA precursors. BCAS2 acts as an ER co-activator and is capable of boosting ER-mediated transcription, suggesting that BCAS2 is involved in the development of breast cancer.
BCAS2 Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 261 amino acids (1-225 a.a.) and having a molecular mass of 30.3kDa. The BCAS2 is purified by proprietary chromatographic techniques.
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