FGF-basic (bFGF or FGF2) is a member of the fibroblast growth factor (FGF) family. FGF family members are heparin-binding multifunctional proteins and are involved in a variety of biological processes including angiogenesis, wound healing, and embryonic development. FGF-basic is known to play a key role during prenatal development and postnatal growth and regeneration of tissues by promoting cellular proliferation and differentiation. FGF-basic has been recognized as a critical component of human embryonic stem cell culture medium due to its vital role for cells to remain in an undifferentiated state. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. This recombinant human FGF-basic consists of 146 amino acid residues. In addition it contains a 10 aa tag at the N-terminus resulting in a 17.8 kDa protein.
Our ISOKineTM growth factors are produced in the endosperm tissue of barley grain (Hordeum vulgare), that exhibits up to 50 times less protease activity than E.coli or mammalian cells. Barley seed is void of any human or animal viral contaminants that could jeopardize your cell culture.
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- Product Publications
- David Xinzheyang Li, Zhiyao Ma, Alexander RA Szojka, Xiaoyi Lan, Melanie Kunze, Aillette Mulet-Sierra, Lindsey Westover, and Adetola B Adesida. (2023). Non-Hypertrophic Chondrogenesis of Mesenchymal Stem Cells through Mechanohypoxia Programing. Journal of Tissue Engineering, 14:1–18. doi: 10.1177/20417314231172574
- A. K. Aissiou, S. Jha, K. Dhunnoo, Z. Ma, D. X. Li, R. Ravin, M. Kunze, K. Wong, and A. B. Adesida. (2023). Transcriptomic Response of Bioengineered Human Cartilage to Parabolic Flight Microgravity is Sex-Dependent. npj Microgravity, 9:5. doi: 10.1038/s41526-023-00255-6
- Tom Kamperman, Niels G. A. Willemen, Cindy Kelder, Michelle Koerselman, Malin Becker, Luanda Lins, Castro Johnbosco, Marcel Karperien, and Jeroen Leijten. (2023). Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli-Responsive Cell-Adhesive Micromaterials. Advanced Science, 2205487. doi: 10.1002/advs.202205487
- Zhiyao Ma, David Xinzheyang Li, Ryan K. W. Chee, Melanie Kunze, Aillette Mulet-Sierra, Mark Sommerfeldt, Lindsey Westover, Daniel Graf, and Adetola B. Adesida. (2022). Mechanical Unloading of Engineered Human Meniscus Models Under Simulated Microgravity: A Transcriptomic Study. Scientific Data, 9:736. doi: 10.1038/s41597-022-01837-x
- Yan Liang, Enaam Idrees, Alexander Szojka, Stephen Andrews, Melanie Kunze, Aillette Mulet-Sierra, Nadr Jomha, Adetola B. Adesida (2018). Chondrogenic Differentiation of Synovial Fluid Mesenchymal Stem Cells on Human Meniscus-Derived Decellularized Matrix Requires Exogenous Growth Factors. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2018.09.038
- Tom Kamperman. (2018). Microgel Technology to Advance Modular Tissue Engineering. Dissertation. DOI: 10.3990/1.9789036544610
- Claas Willem Visser1, Tom Kamperman, Lisanne P. Karbaat, Detlef Lohse1 and Marcel Karperien. In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials. Science Advances 31 Jan 2018: Vol. 4, no. 1, eaao1175 DOI: 10.1126/sciadv.aao1175
- Tom Kamperman, Sieger Henke, Claas Willem Visser, Marcel Karperien, Jeroen Leijten. (2017). Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape. Small, doi: 10.1002/smll.201603711.
- Tom Kamperman ;Sieger Henke, Bram Zoetebier, Niels Ruiterkamp, Rong Wang, Behdad Pouran, Harrie Weinans, Marcel Karperien and Jeroen C.H. Leijten. (2017). Nanoemulsion-induced Enzymatic Crosslinking of Tyramine-functionalized Polymer Droplets. Journal of Materials Chemistry B, doi: 10.1039/C7TB00686A
Product Patent Application
- Tom Kamperman, Lisanne Paula Karbaat, Hermanus Bernadus Johannes Karperin, Jeroen Christianus Hermanus Leijten, Pieter Jelle Dijkstra, and Bram Zoetebier. (2020). Porous Affinity Hydrogel Particles for Reducing the Bioavailability of Selected Biological Molecules. United States Patent Application 20200347125
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