Product Details
Catalog Number: RA10106
Applications: IHC
Type: Rabbit IgG
Immunogen: FGGFTGARKSARKLANQ
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 5368
UniProt: Q13519
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
150 ul$348.00Add to Cart
50 ul$145.00Add to Cart

Orphanin FQ (nociceptin, OFQ), a heptadecapeptide peptide, has been designated as an endogenous ligand for the ORL1 receptor. The amino acid sequence of OFQ has homology with other opioid peptides, especially the prodynorphin fragment  dynorphin A, suggesting a close evolutionary relationship between the precursors. A diffuse distribution throughout the brain is seen with binding studies and in situ hybridization suggesting an extensive role for OFQ in a multitude of CNS functions. Immunocytochemical localizations in rat spinal cord have demonstrated OFQ abundance in superficial dorsal horn, lateral spinal nucleus and the region dorsal to the central canal. OFQ immunoreactivity was not affected by dorsal rhizotomy, indicating that in spinal cord the peptide is produced by central rather than primary afferent neurons. The localization is supported by its function in processing of nociceptive signals.

Supporting Products
NameCatalog #Size
Orphanin FQ/NociceptinP1011150 ul. @ 2 mg/ml. Blocking Peptide
Images
Confocal images showing OFQ (red), GnRH (green) and their colocalization (yellow) in the ovine preoptic area and hypothalamus.

Confocal images showing OFQ (red), GnRH (green) and their colocalization (yellow) in the ovine preoptic area and hypothalamus.More info found at Endocrinology. First published ahead of print July 5, 2007 as doi:10.1210/en.2007-0011

Confocal images showing OFQ (red), GnRH (green) and their colocalization (yellow) in the ovine preoptic area and hypothalamus.

Confocal images showing OFQ (red), GnRH (green) and their colocalization (yellow) in the ovine preoptic area and hypothalamus.More info found at Endocrinology. First published ahead of print July 5, 2007 as doi:10.1210/en.2007-0011