Product Details
Catalog Number: RA10110
Applications: ICC, WB, IHC, IP
Type: Rabbit IgG
Immunogen: RASLDSEESESPPQENSC
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Rat
Entrez: 7442
UniProt: Q8NER1
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
150 ul$456.00Add to Cart
50 ul$215.00Add to Cart

VR1 (vanilloid receptor 1) is a channel activated by capsaicin, the pungent ingredient in hot peppers. It was isolated from sensory neurons. Sequence analysis suggests that VR1 has six transmembrane domains and intracellular N- and C-termini. It shares structural similarities with the family of putative store-operated calcium channels. VR1 is expressed by nociceptive sensory neurons. It is activated by noxious heat and is thought to function as transducer of noxious thermal stimuli.

Supporting Products
NameCatalog #Size
VR1 N-Terminus (TRPV1)P10110100 ug Blocking Peptide
Images
Fragment of Rat Dorsal Root ganglion was stained with rabbit TRPV1 antibody

Fragment of Rat Dorsal Root ganglion was stained with rabbit TRPV1 antibody (Neuromics #RA10110; dilution 1/500; cyan), and IB4-Alexa 594 (Thermofisher #I21413; dilution 1/300). Some DRG neurons express GFP (because they were infected by intrathecal administration of AAV2-5 carrying GFP). Data Courtsey of Timur Mavlyutov, University of Wisconsin

Fragment of Rat Dorsal Root ganglion was stained with rabbit TRPV1 antibody

Fragment of Rat Dorsal Root ganglion was stained with rabbit TRPV1 antibody (Neuromics #RA10110; dilution 1/500; cyan), and IB4-Alexa 594 (Thermofisher #I21413; dilution 1/300). Some DRG neurons express GFP (because they were infected by intrathecal administration of AAV2-5 carrying GFP). Data Courtsey of Timur Mavlyutov, University of Wisconsin

Rat DRGs stained with VR1 antibody (cat# RA10110). The tissue was perfused, cryoprotected in 30% Sucrose-PBS and frozen sectioned to slides at 10um. The tissue was labeled with VR1 (green) at 1:1000 and NeuN (red) at 1:1000. This pictures was taken with an epifluorescent microscope at 10x. Data courtesy of Joanne Steinauer at University of California, San Diego

Rat DRGs stained with VR1 antibody (cat# RA10110). The tissue was perfused, cryoprotected in 30% Sucrose-PBS and frozen sectioned to slides at 10um. The tissue was labeled with VR1 (green) at 1:1000 and NeuN (red) at 1:1000. This pictures was taken with an epifluorescent microscope at 10x. Data courtesy of Joanne Steinauer at University of California, San Diego

TRPV1 binds to the PI3K SH2 domains in a phosphotyrosine-independent manner.

TRPV1 binds to the PI3K SH2 domains in a phosphotyrosine-independent manner. More information can be found in the publication: Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane Alexander T. Stein, Carmen A. Ufret-Vincenty, Li Hua, Luis F. Santana, Sharona E. Gordon The Journal of General Physiology Nov 2006, 128 (5) 509-522; DOI: 10.1085/jgp.200609576

TRPV1 binds to the PI3K SH2 domains in a phosphotyrosine-independent manner.

TRPV1 binds to the PI3K SH2 domains in a phosphotyrosine-independent manner. More information can be found in the publication: Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane Alexander T. Stein, Carmen A. Ufret-Vincenty, Li Hua, Luis F. Santana, Sharona E. Gordon The Journal of General Physiology Nov 2006, 128 (5) 509-522; DOI: 10.1085/jgp.200609576