PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.
It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors.
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- Saban MR, Davis CA, Avelino A, Cruz F, Maier J, Bjorling DE, Sferra TJ, Hurst RE, Saban R. (2011). VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG. BMC Physiology, 11:16. doi: 10.1186/1472-6793-11-16
- Bianka Brunne, Shanting Zhao, Amin Derouiche, Joachim Herz, Petra May, Michael Frotscher, and Hans H. Bock. (2010). Origin, Maturation and Astroglial Transformation of Secondary Radial Glial Cells in the Developing Dentate Gyrus. Glia, 58(13): 1553–1569. doi: 10.1002/glia.21029
- M Ikeuchi, MD, PhD, SJ Kolker, LA Burnes, RY Walder, PhD, and KA Sluka, PT, PhD. (2008). Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice. Pain, doi: 10.1016/j.pain.2008.01.020
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