Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.
Image: mGluR6 (green) and protein kinase C (green) staining of P100 rat retinas. (mGluR6 dilution 1:2000). Raymond D. Lund, Shaomei Wang, Bin Lu, Sergej Girman, Toby Holmes, Yves Sauvé, Darin J. Messina, Ian R. Harris, Anthony J. Kihm, Alexander M. Harmon, Feng-Yi Chin, Anna Gosiewska, Sanjay K. Mistry. Cells Isolated from Umbilical Cord Tissue Rescue Photoreceptors and Visual Functions in a Rodent Model of Retinal Disease.Stem Cells Vol. 25 No. 3 March 2007, pp. 602 -611 doi:10.1634/stemcells.2006-0308; www.StemCells.com © 2007 AlphaMed Press
- Product ReviewsVery good!! Product Name: mGluR6, Rabbit– (Cat# RA13105) http://bit.ly/1fn9Xjp Organization: University of FloridaM - Jul 25, 2014 - Rating: 5.0
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