Product Details
Catalog Number: RA14110
Applications: IHC
Type: Rabbit IgG
Immunogen: (C)KASRWRGRQNREKR
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Rat
Entrez: 150
UniProt: P08913
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
150 ul$456.00Add to Cart
50 ul$190.00Add to Cart

Alpha 2A, 2B, and 2C adrenergic receptors are seven transmembrane receptors that couple to inhibitory G-proteins. Alpha 2C has a wide distribution pattern in the CNS.

On neurons, Alpha 2 adrenergic receptors (alpha 2ARs) are located on both pre- and postsynaptic domains where they mediate an inhibitory role in the central and peripheral nervous system. Alpha 2C has a wide distribution pattern in the CNS. At the spinal cord level the vast majority of alpha 2C is not of primary afferent origin; however, a small fraction of neurons in DRG do express mRNA for alpha 2C and harbor the protein. Colocalization has been observed between alpha 2C and enkephalin in the spinal cord dorsal horn, spinal cord interneurons and α-motoneurons. The distribution pattern of alpha 2C suggests functions at several levels in the brain. Antibody showed positive staining in rat spinal cord dorsal horn, ventral horn motor neurons and retina.

Supporting Products
NameCatalog #Size
Alpha 2a Adrenergic ReceptorP14110100 ug Blocking Peptide
Images

Alpha 2 adrenergic receptor labeling in rat cryostat section of rat brain. Labeling is confined to synaptic boutons (red). Tissue nuclei were counterstasined with DAPI (blue).

Alpha 2 adrenergic receptor labeling in rat cryostat section of rat brain. Labeling is confined to synaptic boutons (red). Tissue nuclei were counterstasined with DAPI (blue).