Alpha 2A, 2B, and 2C adrenergic receptors are seven transmembrane receptors that couple to inhibitory G-proteins. Alpha 2C has a wide distribution pattern in the CNS.
On neurons, Alpha 2 adrenergic receptors (alpha 2ARs) are located on both pre- and postsynaptic domains where they mediate an inhibitory role in the central and peripheral nervous system. Alpha 2C has a wide distribution pattern in the CNS. At the spinal cord level the vast majority of alpha 2C is not of primary afferent origin; however, a small fraction of neurons in DRG do express mRNA for alpha 2C and harbor the protein. Colocalization has been observed between alpha 2C and enkephalin in the spinal cord dorsal horn, spinal cord interneurons and α-motoneurons. The distribution pattern of alpha 2C suggests functions at several levels in the brain. Antibody showed positive staining in rat spinal cord dorsal horn, ventral horn motor neurons and retina.
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- José Tiago Costa-Pereira, Joana Ribeiro, Isabel Martins, and Isaura Tavares. (2020). Role of Spinal Cord α2-Adrenoreceptors in Noradrenergic Inhibition of Nociceptive Transmission During Chemotherapy-Induced Peripheral Neuropathy.Frontiers in Neuroscience, 13:1413. doi: 10.3389/fnins.2019.01413
- T. Fuchigamia, O. Kakinohana, M.P. Hefferan, N. Lukacova, S. Marsala, O. Platoshyn, K. Sugahara, T.L. Yaksh, c, M. Marsal. (2011). Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia. Neuroscience, doi: 10.1016/j.neuroscience.2011.08.022
- Shao-Rui Chen,Hao-Min Pan, Timothy E. Richardson, and Hui-Lin Pan. (2007). Potentiation of Spinal α2-Adrenoceptor Analgesia in Rats Deficient in TRPV1- Expressing Afferent Neurons. Neuropharmacology, doi: 10.1016/j.neuropharm.2007.03.009
- Li D, Atnip LM, Chen S, and Pan H. (2005). Regulation of Synaptic Inputs to Paraventricular-Spinal Output Neurons by 2 Adrenergic Receptors J Neurophysiol, 93: 393-402, 2005. doi: 10.1152/jn.00564.2004
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