100% homology with human and mouse.
The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB and TrkC, exhibiting different ligand specificities, have been identified. At the protein sequence level, Trks are highly conserved between species and the proteins exhibit cross-species activity.
Specificity/Sensitivity: Phospho-TrkA (Tyr490) Antibody detects endogenous levels of Trk only when phosphorylated at tyrosine 490. This antibody also detects TrkB and TrkC when phosphorylated at the corresponding residues.
- Product ReviewsPlaced the order on Aug. 21st received the product on August 23rd. Prompt service coming from the U.S.! Product Name: Phospho-TrkA (Tyr490), rabbit – (Cat# RA18018) http://bit.ly/2flbZqq Organization: University of SaskatchewanShannon - Sep 14, 2017 - Rating: 5.0
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- Product Publications
- Geoffrey E. Bray, Zhengxin Ying, Landon D. Baillie, Ruiling Zhai, Sean J. Mulligan, and Valerie M.K. Verge. (2013). Extracellular pH and Neuronal Depolarization Serve as Dynamic Switches to Rapidly Mobilize trkA to the Membrane of Adult Sensory Neurons. The Journal of Neuroscience, 33(19):8202-8215. doi: 10.1523/JNEUROSCI.4408-12.2013
- Yuan Lu, Yuanyuan Ji, Sundar Ganesan, Robert Schloesser, Keri Martinowich, Mu Sun, Fan Mei, Moses V. Chao, and Bai Lu. (2011). TrkB as a Potential Synaptic and Behavioral Tag. The Journal of Neuroscience, 31(33): 11762-11771. doi: 10.1523/JNEUROSCI.2707-11.2011
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