Product Details
Catalog Number: RA18018
Applications: WB, IHC, IP
Type: Rabbit IgG
Immunogen: Synthetic phosphopeptide corresponding to residue surrounding Tyr490 of human TrkA
Storage: Do not aliquot. Store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Rat
Entrez: 4914
UniProt: P04629
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$387.00Add to Cart

100% homology with human and mouse.

The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB and TrkC, exhibiting different ligand specificities, have been identified. At the protein sequence level, Trks are highly conserved between species and the proteins exhibit cross-species activity.

Specificity/Sensitivity: Phospho-TrkA (Tyr490) Antibody detects endogenous levels of Trk only when phosphorylated at tyrosine 490. This antibody also detects TrkB and TrkC when phosphorylated at the corresponding residues.

Images

Increased mobilization of trkA to neuronal membrane enhances response to NGF challenge. The Journal of Neuroscience, 8 May 2013, 33(19): 8202-8215; doi: 10.1523/​JNEUROSCI.4408-12.2013-phospho-TrkA Customer Publications.

Increased mobilization of trkA to neuronal membrane enhances response to NGF challenge. The Journal of Neuroscience, 8 May 2013, 33(19): 8202-8215; doi: 10.1523/​JNEUROSCI.4408-12.2013-phospho-TrkA Customer Publications.