Product Details
Catalog Number: RA18019
Applications: WB, IHC, IP
Type: Rabbit IgG
Immunogen: Peptide derived from the amino-terminal sequence of human c-Jun
Storage: Do not aliquot. Store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Entrez: 3725
UniProt: P05412
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$332.00Add to Cart

c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 (1,2). Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress-induced signaling pathways. The MAP kinase homologue SAPK/JNK binds to the amino-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun (3,4).

c-Jun also plays a role in Neuropathic Pain.

Images

Confocal immunofluorescent analysis of HeLa cells.

Confocal immunofluorescent analysis of HeLa cells.

Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells, untreated or UV-treated.

Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells, untreated or UV-treated.

Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells, untreated or UV-treated.

Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells, untreated or UV-treated.

Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..

Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..

Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..

Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..