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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $425.00 | Add to Cart |
SHIP1 (SH2-containing inositol phosphatase) is a member of the inositol polyphosphate-5- phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. SHIP2, a homolog of SHIP1, is highly expressed in heart, skeletal muscle and placenta . SHIP2 negatively regulates insulin signaling and polymorphisms in SHIP2 have been linked to hyperglycemia. Recent studies also suggest SHIP2 as a therapeutic target for the treatment of both obesity and type 2 diabetes. Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome. |
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Images
Confocal immunofluorescent analysis of HeLa cells labeled with SHIP2 Antibody (left, green) compared to a nonspecific negative control antibody (right). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).
Confocal immunofluorescent analysis of HeLa cells labeled with SHIP2 Antibody (left, green) compared to a nonspecific negative control antibody (right). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).
Flow cytometric analysis of HeLa cells, using SHIP2 antibody (blue) compared to a nonspecific negative control antibody (red).
Flow cytometric analysis of HeLa cells, using SHIP2 antibody (blue) compared to a nonspecific negative control antibody (red).
Western blot analysis of total cell lysates from SKMEL5 and HeLa cells, using SHIP2 Antibody.
Western blot analysis of total cell lysates from SKMEL5 and HeLa cells, using SHIP2 Antibody.