Product Details
Catalog Number: RA18031
Applications: WB, IP, FC, IF
Type: Rabbit IgG
Immunogen: Synthetic peptide (KLH-coupled) corresponding to residues surrounding Ala1083 of human SHIP2
Storage: Do not aliquot. Store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Rat
Entrez: 3636
UniProt: O15357
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$332.00Add to Cart

SHIP1 (SH2-containing inositol phosphatase) is a member of the inositol polyphosphate-5- phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. SHIP2, a homolog of SHIP1, is highly expressed in heart, skeletal muscle and placenta . SHIP2 negatively regulates insulin signaling and polymorphisms in SHIP2 have been linked to hyperglycemia. Recent studies also suggest SHIP2 as a therapeutic target for the treatment of both obesity and type 2 diabetes.

Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome.

Images

Confocal immunofluorescent analysis of HeLa cells labeled with SHIP2 Antibody (left, green) compared to a nonspecific negative control antibody (right). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).

Confocal immunofluorescent analysis of HeLa cells labeled with SHIP2 Antibody (left, green) compared to a nonspecific negative control antibody (right). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).

Flow cytometric analysis of HeLa cells, using SHIP2 antibody (blue) compared to a nonspecific negative control antibody (red).

Flow cytometric analysis of HeLa cells, using SHIP2 antibody (blue) compared to a nonspecific negative control antibody (red).

Western blot analysis of total cell lysates from SKMEL5 and HeLa cells, using SHIP2 Antibody.

Western blot analysis of total cell lysates from SKMEL5 and HeLa cells, using SHIP2 Antibody.