Product Details
Catalog Number: RA19012
Applications: WB
Type: Rabbit IgG
Dilutions: WB 1:500-1:1000
Immunogen: C terminus of IKAP
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Entrez: 8518
UniProt: O95163
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$250.00Add to Cart

The transcription factor NF-kappa B coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappa B is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes. Theses large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for 3 different kinases involved in pro-inflammatory cytokine signaling.

Images

Western blot of IKAP (1:500) in HEK293 cells stimulated with interleukin-1

Western blot of IKAP (1:500) in HEK293 cells stimulated with interleukin-1