Product Details
Catalog Number: RA19016
Applications: WB, IHC
Type: Rabbit IgG
Dilutions: WB 1:500 - 1:1000
Immunogen: SGPIYPGLFDIRSS of the C-terminus of SHANK1a
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat
Entrez: 50944
UniProt: Q9Y566
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$225.00Add to Cart

Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.

Shank1 A has also been found to be associated with L-type Ca2+ channels.  Olson et al., J Neurosci. 2005, 25:1050-62; Zhang et al., J Neurosci. 2005, 25:1037-49) the same channels used by photoreceptors for transmitter release.

Images

HC Staining in Mouse Retina, Courtesy of Sal Stella, UCLA

HC Staining in Mouse Retina, Courtesy of Sal Stella, UCLA