The human tissue kallikrein gene family contains 15 members that play important roles in cancer. Notably, KLK1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. KLK3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. KLK4 is specifically expressed in the prostate and overexpressed in prostate cancer. KLK5 is widely expressed but found at high levels in skin, breast, brain and testis; overexpression is an indicator of poor prognosis in ovarian cancer. KLK8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.
- Product Reviews
Leave a review for this product and you could be eligible for a $10 Starbucks gift card.
- Product Publications
- Hara M, Fukui R, Hieda E, Kuroiwa M, Bateup HS, Kano T, Greengard P, Nishi A. (2010). Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons. Journal of Neurochemistry, doi: 10.1111/j.1471-4159.2010.06668.x
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Aurora A/B/C kinase MO22139 100 ul Aurora B kinase MO22138 100 ul KLK-3 (PSA) RA19044 100 ug KLK-L1 RA19045 100 ug KLK-L3 (KLK9) RA19047 100 ug KLK-L4 RA19048 100 ug KLK12 RA19049 100 ug KLK14 RA19050 100 ug KLK15 RA19051 100 ug