Alpha 2A, 2B, and 2C adrenergic receptors are seven transmembrane receptors that couple to inhibitory G-proteins. Alpha 2C has a wide distribution pattern in the CNS. On neurons Alpha 2 adrenergic receptors are located on both pre- and postsynaptic domains where they mediate an inhibitory role in the central and peripheral nervous system. Alpha 2C has a wide distribution pattern in the CNS. At the spinal cord level the vast majority of alpha 2C is not of primary afferent origin; however, a small fraction of neurons in DRG do express mRNA for alpha 2C and harbor the protein. Colocalization has been observed between alpha 2C and enkephalin in the spinal cord dorsal horn, suggesting that alpha 2C may be expressed by a subset of spinal interneurons. The distribution pattern of alpha 2C suggests functions at several levels in the brain. Antibody showed positive staining in rat spinal cord dorsal horn, ventral horn motor neurons and retina. When examined in other brain regions known to express α2A staining was not observed.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Alpha 2a Adrenergic Receptor RA14110 150 ul Alpha 2a Adrenergic Receptor RA14110 50 ul Bradykinin Receptor B2 RA14137 100 ul Corticotropin Releasing Hormone Receptor 1 GT41006 100 ug Frizzled 7 RA30031 50 ug Frizzled 9 RA30032 50 ug GPR12 RA30050 50 ug GPR49 RA25071 100 ul GPRC6A RA30049 50 ug Oxytocin RA24604 100 ul Rhodopsin (A531) MO22128 100 ul Rhodopsin (B630) MO22127 100 ul Somatostatin Receptor-1-SSTR1 RA25004 100 ul Somatostatin Receptor-2-SSTR2 RA25005 100 ul