Product Details
Catalog Number: RA19067
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: Synthetic peptide comprising residues 513-526 [TERHGLKEPKRVEE] of the human Nurr1 protein. Reacts with rat and mouse Nurr1.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat
Entrez: 4929
UniProt: P43354
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$275.00Add to Cart

Alternate Names: NOT; NURR1; TINUR; Nuclear Receptor of T Cells; Nuclear Receptor Related 1; Transcriptionally Inducible Nuclear Receptor; Nuclear Receptor Subfamily 4, group A, member 2; nuclear receptor subfamily 4, group A, member 2.

The Nurr1 gene  encodes  a  member  of  the  steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders  related  to  dopaminergic dysfunction,  including Parkinson's. 

Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype.  In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.

Images

Nurr1 staining of rat adult hippocampus. Tissue was fixed in paraformaldehyde and cut in 20 micron sections. Dulution 1:100.

Nurr1 staining of rat adult hippocampus. Tissue was fixed in paraformaldehyde and cut in 20 micron sections. Dulution 1:100.

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