Product Details
Catalog Number: RA19068
Applications: WB
Type: Rabbit IgG
Dilutions: Synthetic peptide comprising residues 281-296 [TRYFSTPQTMDLFLNY] of the human Nanog protein.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Entrez: 79923
UniProt: Q9H9S0
Downloads: Datasheet (pdf)
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This product has been discontinued and is no longer available.

The transcriptional factor Nanog functions in maintaining pluripotency in cooperation with other key genes such as Oct4.  Oct4 and Sox2 bind to the Nanog promoter in mouse and human embryonic stem cell.  Nanog levels allow stem cells to balance the creation of lineage-committed and undifferentiated cells.

Nanog-deficient ES cells lose pluripotency and differentiate into extraembryonic endoderm lineage. Thus it is one of the molecular markers suitable for recognizing the undifferentiated state of stem cells in the mouse and human. NANOG is a new marker for testicular carcinoma in situ and germ cell tumors.

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