The Notch protein sits like a trigger penetrating the cell membrane, with part of it inside and part outside. Proteins when binding to the exterior part cause the release of a portion of the interior part, which typically then makes its way to the cell nucleus to alter gene expression. The Notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine rich EGF like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1,Notch2, Notch3 and Notch4(Int3), which have been implicated in the differentiation of the nervous system and other structures. The EGF like proteins Delta and Serrate have been identified as ligands of Notch1.
Notch signaling is important in embryonic development promotes survival and proliferation of stem cells. This could have positive implications for functional recovery from stroke and Neurodegenerative diseases. Signaling is often repressed in many cancers, and faulty Notch signalling is implicated in many diseases including T-ALL (T-cell acute lymphoblastic leukemia), CADASIL (Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy), MS (Multiple Sclerosis), Tetralogy of Fallot, Alagille syndrome, and myriad other disease states.
- Product Reviews
- Product Publications
- Akihiko Hiyama, Renata Skubutyte, Dessislava Markova, D. Greg Anderson, Sanjay Yadla, Daisuke Sakai, Joji Mochida, Todd J. Albert, Irving M. Shapiro, Makarand V. Risbud. (2011). Hypoxia activates notch signaling pathway in cells of the intervertebral disc: Implications in degenerative disc disease. Arthritis and Rheumatology, doi: 10.1002/art.30246
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Angiopoietin-1 (ANG-1) RA26000 100 ul Artemin RA19009 100 ul BDNF GT41014 100 ug CREB MO18006 100 ul CYR61 RA25061 100 ul FGF-2 MO27001 500 ug GATA3 MO47046 100 ug GDNF Receptor Alpha 3 RA30017 50 ug Her2/Neu MO47003 100 ul IGF1R (Insulin-Like Growth Factor Receptor 1) RA21017 50 ug KDR (Kinase Insert Domain Receptor) RA21018 50 ug Kidins220 (ARMS) RA19019 100 ul Notch1 RA19069 100 ul PCNA MO20014 100 ul phospho-Kidins220 (ARMS) RA19020 100 ul phospho-TrkA(Tyr490) RA18018 100 ul pre-pro Enkephalin RA14142 50 ul PTGDS RA25023 100 ul RHEB RA30052 50 ug SMAD-2 RA21025 50 ug SMAD3 RA30033 50 ug TGF beta MO20012 100 ul. TNFRSF1 (Tumor Necrosis Factor Receptor Superfamily, Member 1A), N terminal region RA21029 50 ug Transforming Growth Factor (TGF) beta 1, middle region RA21028 50 ug VEGF R2 (FLK1/KDR) RA25011 100 ul VEGF R2 (FLK1/KDR) RA25011 500 ul VEGF R3 (Flt-4) MO20013 100 ul Wnt10a RA30027 50 ug Wnt2b RA30030 50 ug Wnt8a RA30029 50 ug