G protein-coupled receptors (GPCRs) are the largest family ofmembrane receptors that activate intracellular signalingcascades and undergo endocytosis, recycling, or degradationupon stimulation. The (mu) m-, delta (d) and kappa (k) opioid receptors areGPCRs of the nervous system, which control pain, stress, andaddictive behaviors. The delta opioid receptor (DOR-1) is the stereoselective receptor for enkephalins and inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
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- Hai-Bo Wanga, Bo Zhaoa, Yan-Qing Zhonga, Kai-Cheng Li, Zi-Yan Li, Qiong Wang, Yin-Jing Lua, Zhen-Ning Zhang, Shao-Qiu He, Han-Cheng Zheng, Sheng-Xi Wu, Tomas G. M. Hökfelt, Lan Baob, and Xu Zhanga. (2010). Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons. PNAS, vol. 107 no. 29 13117-13122. doi: 10.1073/pnas.1008382107
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